The combination of MTX and anti-TNFα antibodies decreased CXCR3 and IL-12R expression (considered a Th1 cell markers) and upregulated CCR4 and IL-4R expression (considered a Th2 cell markers) in peripheral blood CD4 cells in patients with RA, with a high percentage of apoptotic cells (68). This evidence concerns the gene TNF and rheumatoid arthritis.