However, the (opposite) correlation of the loss of T cells specific for the TRP-2 SVY-, TAG-1 SLG- and Telomerase RLF-peptide-MHC complexes with OS noted here might be explained by these cells being dysfunctional or exhausted already before the start of ICB, as commonly reported in advanced stages of cancer (50). The gene discussed is HLA-C; the disease is cancer.