When we generated Treg cell-specific OGT knockout (KO) using the Foxp3YFP-Cre mice with YFP-Cre knocked into the endogenous Foxp3 locus (Figure S1A), hemizygous male KO mice developed scurfy phenotypes and died of autoimmune disease by the age of 4 weeks (38), thus preventing us to study their whole-body metabolism. The gene discussed is FOXP3; the disease is autoimmune disease.