STAT5B and obesity due to melanocortin 4 receptor deficiency: While intestinal lipid absorption is not perturbed, STAT5B-CA-driven Treg cell activation suppresses the expression of key genes involved in adipose fatty acid uptake – Lpl and Cd36. It would be important in the future to determine if the obesity protection in STAT5B-CA overexpression mice is dependent on LPL/CD36 downregulation.