One example is a CAR design that targets a cryptic epitope, the 287–302 amino acid loop in EGFR, which is only exposed and recognized by CAR when the protein is activated, mutated, or overexpressed (tumor cells), whereas the recognition is blocked when the protein is in an inactivated or wild-type status (normal tissues) (64, 65). This evidence concerns the gene EGFR and neoplasm.