KEGG functional analysis of those 135 upregulated DEGs in GM-noTC group identified a variety of proinflammatory pathways ranked in top 15 terms, including cytokine-cytokine receptor interaction, TNF signaling pathway and IL-17 signaling pathway, as well as inflammatory diseases, such as inflammatory bowel disease (Figure 2D). The gene discussed is IL17A; the disease is inflammatory bowel disease.