DHFR and uterine cancer: Based on mutant (n = 19) versus wild-type (n = 507) in uterine cancer, IL22RA1 mutation upregulated 156 genes, which involved in DNA repair (fanconi anemia pathway [SLX4, RAD51, EME1, FANCA, BRCA1], homologous recombination [RAD51, EME1, RBBP8, BRCA1]), and one carbon pool by folate [DHFR, MTHFD2L, TYMS], whereas downregulated 59 genes involving alcoholic liver disease (C3, PRKAG2, PPARGC1A) and the FoxO signaling pathway (CDKN2B, BCL6, PRKAG2) (Figure 4B).