Based on mutant (n = 19) versus wild-type (n = 507) in uterine cancer, IL22RA1 mutation upregulated 156 genes, which involved in DNA repair (fanconi anemia pathway [SLX4, RAD51, EME1, FANCA, BRCA1], homologous recombination [RAD51, EME1, RBBP8, BRCA1]), and one carbon pool by folate [DHFR, MTHFD2L, TYMS], whereas downregulated 59 genes involving alcoholic liver disease (C3, PRKAG2, PPARGC1A) and the FoxO signaling pathway (CDKN2B, BCL6, PRKAG2) (Figure 4B). This evidence concerns the gene MTHFD2L and alcoholic liver diseases.