Of these five patients with new PID related VUS(s), two patients (19S and 59S) had a single VUS in an AR/autosomal dominant (AD) gene: FLG and SERPING1, respectively, and three patients (29S, 31S, 49S) had a single VUS in an AD gene: OAS1, TNFAIP3 and NFKB1, respectively. Here, FLG is linked to Alzheimer disease.