The top 20 mutated genes TTN, MUC16, LRP1B, ARID1A, CSMD3, SYNE1, FAT4, PCLO, HMCN1, ZFHX4, CSMD1, SPTA1, KMT2D, FAT3, DNAH5, OBSCN, RYR2, LRRK2, FLG, and SYNE2 were identified in patients with STAD (Figure 4C). Here, SYNE2 is linked to gastric adenocarcinoma.