The top 20 mutated genes TTN, MUC16, LRP1B, ARID1A, CSMD3, SYNE1, FAT4, PCLO, HMCN1, ZFHX4, CSMD1, SPTA1, KMT2D, FAT3, DNAH5, OBSCN, RYR2, LRRK2, FLG, and SYNE2 were identified in patients with STAD (Figure 4C). This evidence concerns the gene RYR2 and gastric adenocarcinoma.