CD8A and neoplasm: To test this, we challenged cohorts of C57BL/6J Nkg7+/+ and Nkg7-/- littermate mice with the mouse colon carcinoma tumor line, MC38-OVA; a model in which the growth of tumors is acutely controlled by endogenous OVA-reactive CD8+ T cells in the 3 weeks following tumor inoculation (14).