TNFRSF1A and neoplasm: However, whereas previously we did not observe any significant differences in MC38-OVA tumor growth in Nkg7+/+ and Nkg7-/- mice (Figure 1E), in the absence of tumor cell TNFR1 signaling (as in MC38-OVA-Tnfrsf1a-/- cells), there was a significant reduction in tumor control in Nkg7-/- mice compared to Nkg7+/+ littermates (Figures 6J–M).