In this experiment, the data demonstrated that, after hepatocyte-conditional knockout of PEBP4, all the inflammatory indicators (pathological changes, MPO activity, IL-1β, TNF-α, and COX-2) were more significantly serious in CKO mice, suggesting PEBP4 CKO could promote inflammation and PEBP4 may be a target to control ALI. This evidence concerns the gene TNF and acute respiratory distress syndrome.