NLRP3 and colitis: Indeed, the role of NLRP3 in the regulation of intestinal homeostasis was previously elucidated, since NLRP3-/- mice are more susceptible to the development of experimentally induced colitis (31).Additionally, it was demonstrated that the administration of A. muciniphila induced the proliferation of intestinal stem cells and boosted the differentiation of Paneth and goblet cells in the small intestine and colon of healthy mice or mice with gut damage caused by radiation and methotrexate.