In sum, the present work elucidated that overexpression of lncRNA-XLOC_006390 in colorectal cancer leads to repression in the expression of tumor-suppressor miR-296-3p which in turn enhances transcript and protein levels of ONECUT 2 transcription factor, and the latter enables high proliferation and metastasis of colorectal cancer cells. This evidence concerns the gene ONECUT2 and neoplasm.