TP53 and neoplasm: As expected, the prognostic signature was enriched in Kappa B kinase NF-κB signaling, the regulation of extrinsic apoptotic signaling pathway, the apoptosis, the focal adhesion, and the Toll-like receptor signaling pathway, the P53 pathway, and the TNFα signaling via NF-κB, all of which were important signaling pathways regulating tumor proliferation and tumor progression.