The findings illuminated (Figure 5(a)) that compared with the blank control (vector), overexpression of lncRNA ZNF674-AS1 inhibited the expression of key proteins HK2, PFKL, PKM2, and GLUT1 in the glycolysis process of liver cancer SMMC-7721 and HepG2 cells. This evidence concerns the gene ZNF674 and liver cancer.