SPG11 and early-onset autosomal dominant Alzheimer disease: We note that Als5 might have main and minor aggregation sites, with the latter taking over in case of interference or mutation in the main site, as previously suggested for Tau involved in Alzheimer’s disease and for Fap amyloids involved in the biofilm of Pseudomonas (Christensen et al., 2019; Annadurai et al., 2022).