IRF3 and viral infectious disease: DDX3X physically interacts with IκB kinase ε (IKKε) (Schröder et al., 2008), TANK Binding Kinase 1 (TBK1) (Soulat et al., 2008), TNF Receptor Associated Factor 3 (TRAF3) (Gu et al., 2017), and Interferon regulatory factor 3 (IRF3) (Gu et al., 2013), resulting in enhanced type I IFN production upon viral infection or synthetic dsRNAs treatment in mammalian cells.