Although specific expression profiles of miRNAs, lnRNAs, and cirRNAs have been well-documented in the literature (Padgett et al., 2009; Sigdel et al., 2015; Zheng et al., 2017a), the underlying mechanisms of ncRNAs in the development of PBC is unclear and may involve autoimmune regulatory pathways such as TGF-B1, NF-kB, Th17, and TCR. This evidence concerns the gene TGFB1 and primary biliary cholangitis.