IGHE and Alzheimer disease: In Rochester cohort, 20 infants (25%) were diagnosed with AD, 9 infants (11%) with IgE-mediated FA, 3 infants (4%) with allergic proctocolitis, 2 infants (3%) with ARC, and 1 infant (1%) with recurrent wheeze by 12 months of age; in OOM cohort, 2 infants (3%) were diagnosed with AD (Figure 3A).