Cytokines, including interleukin 6 (IL-6), interleukin 8 (IL-8), gamma interferon (IFN-γ), and tumor necrosis factor alpha (TNF-α), and cell surface antigens such as soluble intercellular adhesion molecule (sICAM) and CD64, have been studied as measures for neonatal sepsis; however, the heterogeneity of available evidence prevents conclusions regarding their routine use as definitive diagnostic tools (38, 65, 66). Here, TNF is linked to Neonatal sepsis.