PRKG1 and hypertrophic cardiomyopathy: GSH supplementation could reverse the mechanical disturbances and restore the elevated Fpassive in hypertrophic cardiomyopathy and HFpEF cardiomyocytes from patients and animal models, suggesting the oxidative stress-induced modifications in PKG pathway to play a crucial role in HFpEF and hypertrophic cardiomyopathy pathology (Hassoun et al., 2021; Kolijn et al., 2021).