CAMK2G and cardiac hypertrophy: CaMKII isoforms show increased expression/activity both in failing human hearts and in animal models of cardiac hypertrophy (Anderson et al., 2011; Hamdani et al., 2013d) Furthermore, overexpression of CaMKIIδC in mouse myocardium is associated with massive cardiac hypertrophy and induces dilated cardiomyopathy and premature death, whereas knockout of the CaMKIIδ-isoform in mice attenuates pathological cardiac hypertrophy and remodelling in response to pressure overload (Backs et al., 2009; Ling et al., 2009).