He et al. (He M. Q. et al., 2020) found that LDL cholesterol and total cholesterol were more elevated after 9 weeks of a low sucrose, 60% fat diet protocol in C57BL/6 mice than after 5 weeks; therefore, a longer duration of study and perhaps a different diet composition to that used in the current study would be beneficial for studying the impact of TLR7-driven autoimmunity on other components of dyslipidemia. Here, TLR7 is linked to metabolic syndrome.