Genome-wide association studies report polymorphisms in the TLR7 locus segregating with SLE (Shen et al., 2010; dos Santos et al., 2012) and more recently, a gain-of-function mutation in TLR7 was identified in a pediatric SLE patient (Brown et al., 2022). This evidence concerns the gene TLR7 and systemic lupus erythematosus.