NRG1 and myocardial infarction: Besides, endothelial derived NRG1 was shown to promotes ischemia-induced angiogenesis and arteriogenesis in the setting of hind limb ischemia (Hedhli et al., 2012) which may explains the deleterious effect of endothelial specific KO of Nrg1 in the setting of myocardial infarction.