More strikingly, when cardiac hypertrophy was provoked either by transverse aortic constriction (TAC) (Izumiya et al., 2006) or AKT Serine/Threonine Kinase 1 (AKT1) overexpression (Shiojima et al., 2005) in cardiomyocytes, inhibiting angiogenesis by soluble FKL1 was shown to prevent cardiac hypertrophy. The gene discussed is AKT1; the disease is cardiac hypertrophy.