Studies have demonstrated that genetic modification of endothelial properties, alone is sufficient to cause HF; this is the case of Platelet and EC Adhesion Molecule 1 (Pecam1) disruption, constitutive activation of Catenin Beta 1 (CTNNB1), Sirtuin 3 (Sirt3) disruption, Sirtuin 1 (Sirt1) disruption, Recombination Signal Binding Protein for Immunoglobulin kappa J region (Rbpj) deletion, EPH Receptor B4 (EphB4) deletion, β3-Adrenergic Receptor (ADRB3) overexpression and NOX2 overexpression (Table 1). This evidence concerns the gene SIRT1 and hydrops fetalis.