Notably, Src blockade which stabilizes a FLK1/Cadherin 5 (CDH5) complex was shown to reduce edema and tissue injury following myocardial infarction (Weis et al., 2004), VEGF-C/VEGFR-3 axes were shown to protect against pressure-overload-induced cardiac dysfunction through regulation of lymphangiogenesis (Lin et al., 2021), Also, CU06-1004 was shown to enhance vascular integrity and improve cardiac remodeling by suppressing edema and inflammation upon myocardial ischemia-reperfusion injury (Zhang H. et al., 2022). This evidence concerns the gene CDH5 and myocardial infarction.