Previous study by our group showed that DsbA-L could inhibit the activation of NLRP3 by activating AMPK phosphorylation in the kidney of DKD mice, while the expression levels of IL-18 and IL-1β were increased in that of DKD mice treated with compound C (an AMPK inhibitor) (Yang et al., 2021a). This evidence concerns the gene IL18 and diabetic kidney disease.