In this study, we first identified hypoxia-related candidate genes between ruptured and stable AAA by performing combination analysis with differential analysis, ssGSEA hypoxia score analysis, and WGCNA on the GSE98278 dataset, verified the differential expression of candidate genes in the GSE17901 dataset, and finally selected two hub genes, MEDAG and SERPINE1. The gene discussed is MEDAG; the disease is triple-A syndrome.