To further understand how miRNAs are involved in the regulation of MEDAG and SERPINE1 and to gain insights into these mechanisms, we constructed a ceRNA network diagram in which miR-21-5p downregulation of MEDAG and SERPINE1 was associated with AAA hypoxia and rupture, which is consistent with findings from previously published studies (Plana et al., 2020). The gene discussed is MEDAG; the disease is triple-A syndrome.