To further understand how miRNAs are involved in the regulation of MEDAG and SERPINE1 and to gain insights into these mechanisms, we constructed a ceRNA network diagram in which miR-21-5p downregulation of MEDAG and SERPINE1 was associated with AAA hypoxia and rupture, which is consistent with findings from previously published studies (Plana et al., 2020). This evidence concerns the gene SERPINE1 and triple-A syndrome.