PRPF40A and lung cancer: In fact, in the literature, it is reported that an over-expression of the PRPF40A gene is associated with an upregulation of biochemical pathways linked to hypoxia and oxidative stress conditions (Oleksiewicz et al., 2017), and it is reported that PRPF40A expression level could be considered a reliable marker of hypoxia-induced stress in human lung cancer (Huo et al., 2019; Ancel et al., 2021).