AKT1 and hepatocellular carcinoma: For example, Quercetin induces apoptosis in hepatocellular carcinoma cells in vivo and in vitro by regulating multiple pathways such as PI3K/Akt, MAPK/ERK, and JAK/STAT (Fernandez-Palanca et al., 2019; Ji et al., 2019; Salama et al., 2019; Wu et al., 2019a; Yamada, Matsushima-Nishiwaki & Kozawa, 2021).