When analyzed according to baseline DM, our study demonstrated a more predominant effect of FPG variability on digestive cancers among nondiabetic participants than those with diabetes, which may attribute to a number of factors, including that the effects of glycemic variability on the risk of cancer might be blunted by chronic hyperglycemia in subjects with diabetes, as well as some hypoglycemic agents such as metformin [36], thiazolidinediones [37], and sodium-glucose cotransporter-2 inhibitor [38] may exert beneficial effects on preventing digestive cancers. The gene discussed is SLC5A2; the disease is cancer.