PMS causes are still unclear and are multifactorial [10, 11] probably as a consequence of interaction and biochemical changes amid the menstrual cycle's hormonal fluctuations (imbalance like progesterone deficiency and estrogen excess) [8] with central neurotransmitters (γ-aminobutyric (GABA) and cholecystokinin serotonin) and altered brain processes [5], genetic vulnerability, and regulation of the renin-angiotensin-aldosterone system [12–14]. Here, REN is linked to premenstrual tension.