Although our study did not further explore the advantages and disadvantages of high expression of HIF-1α in the kidneys of SI-AKI mice, the decrease in HIF-1α expression in the kidneys of mice with pharmacological and genetic inhibition of XO did not rule out the improvement of cellular hypoxia increased the degradation of HIF-1α, which further enriched the effect of XO inhibition in improving renal medulla hypoxia. Here, HIF1A is linked to acute kidney injury.