CRH and atrial fibrillation: In the results, compared with the normal group, the ACTH, CORT and CRH content in model group was significantly decreased (P < 0.01, P < 0.001), PF significantly increased these contents (P < 0.05), and the paeoniflorin group had an increased ACTH content (P < 0.05), while AF also demonstrated an increase (Figure 2D).