We studied a sample of 57 FTD Portuguese patients, by performing exome sequencing and (1) prioritizing potential FTD and ALS causing variants by using Exomiser to annotate and filter results; and (2) looking specifically at rare variability in genes associated with FTD (excluding GRN, MAPT and C9ORF72) and/or ALS. This evidence concerns the gene MAPT and amyotrophic lateral sclerosis.