PLA2G6 and neurodegeneration with brain iron accumulation 2A: In 2006, PLA2G6 was firstly identified as a causative gene for INAD by Morgan, after which molecular testing was promoted as the definitive diagnosis of INAD and this eliminated the need for invasive biopsies, while also enabling the detection of carriers of INAD-associated mutations and allowing for prenatal diagnosis and pre-implantation genetic diagnosis (19, 34).