Across several animal and cellular models of PD (MPTP, 6-OHDA, rotenone), it was reported that different GLP-1R agonists or GLP-1 mimic can promote neurogenesis, neuronal differentiation, and autophagy, as well as increasing nutritional factors, inhibiting neuronal apoptosis, dampening microglial reactivity, enhancing anti-inflammatory/antioxidant effects, and reducing α-Syn expression [6, 7, 9, 10, 42, 43]. The gene discussed is GCG; the disease is Parkinson disease.