While TRPV1 antagonists could play a potential role in the treatment of humans AD (71, 75), nothing can be said about dog AD yet, also given that in the current study the keratinocytes of the AD-dogs did not show significant upregulation of TRPV1-IR in the suprabasal layer cells when compared to the CTRL-dogs. The gene discussed is TRPV1; the disease is Alzheimer disease.