In AD-like murine models, a TRPV1 antagonist (PAC-14028) was seen to show antipruritic effects, to improve skin barrier functions and to suppress the allergic inflammation by means of the modulation of epidermal differentiation markers which blocked the secretion of neuropeptides and suppressed Th2 cytokines (75–77). This evidence concerns the gene TRPV1 and Alzheimer disease.