This locus overlaps a 100 Mb region on chromosome 5 (125855350-125963352), which includes the coding sequence of ALDH4A1 and 69 variants that were nominally associated with TB progression risk in our cohort (Table S13).4, 5, 6, 7 However, understanding whether any of these variants or other variants in this locus might explain the observed admixture mapping signal requires further investigation. Here, ALDH4A1 is linked to tuberculosis.