The anti-acne effect of licorice flavonoids, such as kaempferol, quercetin, naringin, formononetin, and luteolin, might be mediated by the inhibition of the PI3K-Akt pathway, leading to an increase in FoxO1 expression level in the skin to suppress the mTORC1 biological activity, which in turn finally restrains SREBP-1 expression and lipid synthesis [6]. The gene discussed is SREBF1; the disease is acne.