It has also been reported that AKT1 expressed by neutrophils is downregulated during bacterial infection and neutrophil activation, and in the mouse models of ALI and S. aureus infection, AKT1 deficiency resulted in severe disease progression with concomitant neutrophil recruitment and enhanced antimicrobial activity, and the AKT1-STAT1 signaling axis may negatively regulate neutrophil recruitment and activation in these ALI mice (Liu et al., 2013). Here, STAT1 is linked to acute respiratory distress syndrome.