STAT3 and colitis: In TNBS-induced colitis, Berberine increases the expression of sIgA in the colon by downregulating STAT1 and STAT3 phosphorylation, inhibiting the NF-κB signaling pathway, decreasing Th1/Th17, and reducing pro-inflammatory cytokines, which can regulate the immune response homeostasis (Li et al., 2015).