Oxymatrine treatment has a significant regulatory effect on apoptosis by blocking the TLR-9/MyD88/NF-κB pathway associated with downstream TNF-α, IL-1β, and IL-6 protein expression levels, restoring TJ protein expression and attenuating TNBS-induced colitis symptoms (Li et al., 2022). Here, NFKB1 is linked to colitis.