FOXP3 and inflammatory bowel disease: Tripterygium wilfordii polyglycosides can modulate Th17/Treg imbalance in IBD patients by inhibiting Th17 cell differentiation, promoting Tregs differentiation, and modulating inflammatory cytokines by enhancing the in-situ levels of Foxp3+ Tregs, which in turn reduces microscopic inflammation (Li et al., 2014).