EIF2A and renal fibrosis: Mechanistically, BV treatment led to ROS generation and the activation of the Bip/eIF2α/CHOP signaling pathway and subsequently caused ER stress, UPR, and cytoplasmic Ca2+ overloading, both of which in turn regulated the expressions of classical signals involved in EMT and fibrosis, ultimately resulting in renal fibrosis in renal tubular epithelial cells.