Mechanistically, many upstream signaling pathways, including TGF-β, Wnt, and Notch1, were well-documented to regulate the developmental EMT and renal fibrosis (Edeling, Ragi, Huang, Pavenstadt, & Susztak, 2016; J.; Su W. et al., 2020). This evidence concerns the gene NOTCH1 and renal fibrosis.