Improved radiosensitivity in glioma cell lines (T98G, UVW, and U-373G).Improved radiosensitivity of pediatric high-grade glioma, ependymomas, and medulloblastoma cell lines.On the other hand, it is found to be a substrate for ABC transporters and has poor BBB penetration. The gene discussed is ABCG2; the disease is ependymoma.