KCNMA1 and infection: The SLO monomer binds to the host cell membrane through the conserved region of the C-terminal domain 4 (D4), then forms a protein multimer to create a barrel structure that enables it to penetrate the host cell, resulting in cell lysis and subsequent organ system dysfunction during invasive infections (Tweten, 2005; Rossjohn et al., 2007; Mozola and Caparon, 2015; van Pee et al., 2017).