In our studies on the effects of curcumin against the metastatic process of an aggressive model of rat MM, we found several members of the S100 protein family were affected, and to the best of our knowledge these were the first reports showing the impact of this phytochemical simultaneously on S100A4, S100A6, S100A8 and S100A11 (Pouliquen et al., 2020; 2020b; 2021). The gene discussed is S100A11; the disease is Miyoshi myopathy.