To date, the interconnection between H2O2 signaling and EMT in cancer is well established (Milton and Konrad, 2022), and the role of H2O2 producers NADPH oxidase 4 (NOX4), dual oxidase 1 (DUOX1) and DUOX2 in cell motility and metastasis in cancer biology has been reviewed (Meitzler et al., 2019). Here, NOX4 is linked to cancer.