EIF4A1 and gastric cancer: However, the eIF4F translation initiation complex also contains the ATP-dependent DEAD box RNA helicase eIF4A which remodels the 5′-proximal secondary structure for facilitating 40S ribosome recruitment, and a mechanical study revealed that one of the two isoforms, eIF4A1, functioned as an enhancer of EMT in gastric cancer (Gao et al., 2020).