RAC1 and gastric cancer: In this field of research, miRNA-150 was found to repress both Wnt and Hedgehog pathways in gastric cancer (Peng Y. et al., 2021), while miR-375 regulated the Hedgehog pathway via Ras-related C3 botulinum toxin substrate 1 (RAC1) (Liang et al., 2021) (Figure 3).