Interestingly, the combined decrease in S100A4 and fibronectin levels we specifically observed in the spleen of curcumin-treated rats (Pouliquen et al., 2021) found an echo in the findings of one previous study reporting a connection between Hedgehog signaling and S100a4 regulation in pancreatic cancer cells (Xu et al., 2014). The gene discussed is S100A4; the disease is pancreatic neoplasm.