CAFs isolated from lung adenocarcinoma tumors promoted EMT via production of stromal-derived factor-1 (SDF-1), making it possible to identify C-X-C chemokine receptor type 4 (CXCR4)/β-catenin/peroxisome proliferator-activated receptor gamma (PPARδ) signaling in this process (Wang Y. et al., 2021). The gene discussed is CXCR4; the disease is lung adenocarcinoma.