Together with S100A4, S100A6 is the most widely documented protein in the S100 family and is a potential biomarker of tumor invasiveness in proteomics in MM and other cancers (Pouliquen et al., 2020b), and their combined involvement in breast cancer cell proliferation and motility was recognized early (Fang et al., 2009). Here, S100A6 is linked to Miyoshi myopathy.