Regarding MDSCs, the distinct role of the different subsets in tumor EMT was reviewed (Cai et al., 2021a), while inducing EMT and metastatic properties in lung cancer cells was found to be promoted by MDSCs through CCL11 and the activation of ERK and AKT signaling (Lin S. et al., 2021). The gene discussed is AKT1; the disease is neoplasm.