In this field, Zheng et al. recently reported, in an analysis of 431 gastric cancer samples, its impact on changes in tumor stroma components, as a gene set enrichment analysis revealed that EMT, TGF-β signaling, hypoxia, and angiogenesis gene sets were significantly enriched in CAFs, and linked with a worse prognosis (Zheng H. et al., 2021). This evidence concerns the gene TGFB1 and neoplasm.