NFKB1 and cancer: In parallel, as circular RNAs appeared to play an important role in the relationship between inflammation and cancer, TNF-α was found to induce the expression of circSND1 through the transcription factor NF-κB, its function being exerted via a TNF-α/NF-κB/circSND1/miR-125a-3p/FUT6/NF-κB positive regulatory circuit (Bai et al., 2021).