In pancreatic cancer, Takehara et al. (2020) also reported the ability of adipocytes to de-differentiate to CAAs when co-cultured with cancer cells, EMT being induced in the latter via expression of serum amyloid A1 (SAA1), a pro-inflammatory cytokine also expressed in breast cancer cells and TAMs, leading to poorer prognosis in patients. The gene discussed is SAA1; the disease is familial pancreatic carcinoma.