Upstream of Akt, downregulation of the MAPK/ERK protein serine kinase MEK2 (MA2K2) was also reported (Chiu et al., 2021), thus, effectively, inhibiting proliferation and inducing apoptosis by curcuminoids in cancer cells can involve the p38 MAPK pathway (He et al., 2021; Su et al., 2021) (Figure 3). This evidence concerns the gene AKT1 and cancer.