Additionally, Shi et al. (2020) found that the NF-κB p65 signaling pathway, when activated, epigenetically repressed pleckstrin and Sec7 domain-containing 4 (PSD4), a tumor suppressor gene that inhibits the proliferation, migration, and invasiveness of hepatocellular carcinoma (Figure 3). This evidence concerns the gene PSD4 and hepatocellular carcinoma.