Hypoxia and the HIF signaling pathway led to enrichment in CSCs, and curcumin/curcuminoid effects against cancer EMT are mediated through its action on this major tumor microenvironment factor, through a decrease in the expression of miR-21, miR-210, IL-6, HIF-1α, and VEGF (Bao et al., 2012b). The gene discussed is VEGFA; the disease is cancer.