In addition, the molecular hub genes like MAPK14, FOS, MAPK1, and JUN may simultaneously locate in different signaling pathways involved in the AGE-RAGE signaling pathway in diabetic complications, lipid and atherosclerosis, fluid shear stress and atherosclerosis, IL-17 signaling pathway, TNF signaling pathway, Kaposi sarcoma-associated herpesvirus infection, hepatitis B, HIF-1 signaling pathway, human cytomegalovirus infection, and Chagas disease, which means that some co-expression genes scattered in different signaling pathways. The gene discussed is FOS; the disease is atherosclerosis.