CNR1 and Anxiety: Cannabinoid type 1 receptors (CB1R) are highly expressed in the brain areas (Evans and Van'T, 1975; Tsou et al., 1998; Fletcher-Jones et al., 2020) and are related to the control of anxiety response (Haller et al., 2004; Rey et al., 2012) and pain process (Padilla-Coreano et al., 2016; Wang et al., 2020), such as vHPC in particular.