How metformin fits into this interaction is not well studied—in cancer cells metformin has been shown to cause cell death by activating AMPK and thus inhibiting Akt (Wang Y. et al., 2018; Lu et al., 2019; Chen et al., 2021), but data in non-tumor cells is scarce (Kovacic et al., 2003). This evidence concerns the gene AKT1 and neoplasm.