Other genetic abnormalities that may contribute to the development of HCC in NAFLD patients include the C282Y and H63D mutations in the human haemostatic iron regulator (HFE) gene (Bugianesi et al., 2002; Bugianesi et al., 2004; Nelson et al., 2007) and the membrane bound O-acyltransferase structural domain 7 (MBOAT7) gene rs641738 C > T variant (Donati et al., 2017). The gene discussed is MBOAT7; the disease is hepatocellular carcinoma.