Additionally, lncRNA maternally expressed gene 3 (MEG3) induced pyroptotic cell death in triple-negative breast cancer via MEG3/NLRP3/caspase-1/GSDMD signaling pathway in response to cisplatin treatment, which performed an anti-tumor effect both in vitro and in vivo (Yan et al., 2021). This evidence concerns the gene MEG3 and neoplasm.