For example, sorafenib could motivate the cytotoxicity of natural killer cells (NKs) to hepatocellular carcinoma (HCC) cells by inducing the pyroptotic cell death in macrophages, and this effect was significantly related to the secretion of IL-18 and IL-1β (Hage et al., 2019). The gene discussed is IL1B; the disease is hepatocellular carcinoma.