The essential point is that inflammatory cell death effectively recruits a variety of lymphocytes (including CD8+T cells) and macrophages into the tumor microenvironment, which successfully ignite the immune environment to convert immunologically insensitive tumors into sensitive ones, and this phenomenon is attributed to the secretion of inflammatory cytokines (like IL18, IL1β, ATP, and HMGB1) caused by pyroptosis (Tang et al., 2020; Rosenbaum et al., 2021). Here, HMGB1 is linked to neoplasm.