The DEGs between healthy SVZ and GBM were mainly enriched in tumor-related pathways, such as the PI3K-Akt, NF-κb, and JAK-STAT signaling pathways, which are strongly correlated with the occurrence and development of glioma and immune-related functions, including regulation of T cell differentiation and humoral immune response (Aldape et al., 2015; Mao et al., 2012). Here, NFKB1 is linked to central nervous system cancer.