Several studies have focused on the prognostic values of CAF-related genes in other cancers, a 4-CAF-gene (COL8A1, SPOCK1, AEBP1 and TIMP2) prognostic signature was developed to predict the clinical outcomes and the response to anti-tumor therapies in gastric cancer (Zheng et al., 2021). The gene discussed is TIMP2; the disease is cancer.