The GO and KEGG pathway analyses of the 362 aberrantly expressed mRNAs revealed the crucial BPs and pathways in GBM, most of which were classic pathways and BPs that play important roles in GBM, such as extracellular matrix, regulation of the mitotic cell cycle, the p53 signaling pathway, the HIF-1 signaling pathway, and the NF-kappa B signaling pathway. The gene discussed is TP53; the disease is glioblastoma.